Acetic Anhydride → HCID 20522156, compound

Participants

Reaction Steps

t-BOC THIP (7.2 g) was refluxed with acetic acid anhydride (5.0 g) in 50 ml of CHCl3 for 2 hours. 2-Acetyl-6-(t-butyloxycarbonyl)-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-one was isolated as an oil in 6.4 g (76%) yield by column chromatography (Silicagel 60 "Merck") (eluted with ether/CH2Cl2 (1:3)). The t-BOC group was split off as above, yielding 73% of the oxalate. M.P. 177°-178° C. (dec.) (Found: C 44.32; H 4.70; N (10.58); C10H12N2O7 requires C 44.12; H 4.45; N 10.29%).

Provenance & Evidence