(4-Fluorophenyl)hydrazine → HCID 87517094, compound

HRID 2233754Notes

Reaction equation

HRID 2233754 reaction equation
O=[C:2]([CH3:15])[CH2:3][O:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23][NH2:24])=[CH:19][CH:18]=1>C(O)C>[F:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23]/[N:24]=[C:2](/[CH3:15])\[CH2:3][O:4][C:5]2[CH:6]=[CH:7][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:13][CH:14]=2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 69982(4-Fluorophenyl)hydrazineHCID 21832186Methyl 4-(2-oxopropoxy)benzoate

Product 1

HCID 87517094HCID 87517094, compoundYield 51.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 4-(2-oxopropoxy)benzoate (6.21 g) was added to a solution of 4-fluorophenylhydrazine (2.88 g) in ethanol (50 ml). After 1.5 h the precipitate was collected, washed with ethanol and isohexane and dried to give the sub-title compound (3.72 g).

Workup

  1. customAfter 1.5 h the precipitate was collected
  2. washwashed with ethanol and isohexane
  3. customdried

Sources & evidence

ORD record
ord-e44b3d2dfe70403eabf4a09740541b5f
Source dataset
uspto-grants-2010_05
Patent number
US07709521B2

Reaction notes

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