HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 68616146, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 3-(4-Carboxyphenoxy)-5-fluoro-2-methyl-1h-indole-1-acetic acid | HCID 11602604 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 68616146 | HCID 68616146 | — |
Reaction Steps
HATU (294 mg) was added to a solution of the product from Example 9 (208 mg) and Hunig's base (0.3 ml) in NMP (1.2 ml). After 10 min a solution of methylamine in THF (0.4 ml, 2M) was added and stirred for 20 h. 2M HCl (1 ml) was added and the mixture was extracted with ethyl acetate. The organic extracts were dried (MgSO4), evaporated, re-dissolved in methanol and treated with a solution of trimethylsilyldiazomethan (1 ml, 2M in ether). Evaporation and purification by chromatography (silica, petrol—acetone as eluent) gave the sub-title compound (177 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709521B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-4ddaa1e00038467bb49d7458cd043b36 |
| Source note | uspto-grants-2010_05 |