Triphenylarsine → HCID 11610887, compound

Participants

Reaction Conditions

Reaction Steps

The product from step (i) (250 mg), 2-(tributylstannyl)-pyrazine (260 mg), Pd (dba)2 (30 mg) and triphenyl-arsine (210 mg) were dissolved in toluene (4 ml) and heated at 90° C. for 20 h. The reaction was cooled to RT, methanol (10 ml) added, followed by 1M aqueous sodium hydroxide (2 ml) and stirred for 20 h. The mixture was diluted with water, extracted with EtOAc, washed with brine, dried (MgSO4), filtered and evaporated. The residue was purified using reverse phase preparative chromatography (eluent MeCN/NH3(aq)) to give the title compound. Yield 30 mg.

Provenance & Evidence