Water → HCID 68617701, compound

Participants

Reaction Steps

A solution of oxone (1.0 g) in water (30 ml) was added to a solution of the product from step (ii) (1.4 g) in acetonitrile (100 ml) and stirred for 2 h. Further oxone (500 mg) was added and the reaction stirred for a further 3 h. The mixture was evaporated to ˜50 ml, extracted with EtOAc, washed with aqueous sodium metabisulphite and brine, dried (MgSO4), filtered and evaporated. The residue was purified by chromatography on silica eluting with 30% etlhylacetate/iso-hexane.

Provenance & Evidence