HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-5-fluoro-1,2-phenylenediamine → 5-chloro-6-fluoro-2-methyl-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-5-fluoro-1,2-phenylenediamine | HCID 735773 | — |
| Reactant | Ethyl ortho-acetate | HCID 86598186 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-chloro-6-fluoro-2-methyl-1H-benzimidazole | HCID 55281565 | 39% |
Reaction Steps
A 4.96 g portion of ethyl orthoacetate dissolved in 10 ml of ethanol was added to 50 ml of ethanol solution containing 4.68 g of 4-chloro-5-fluorobenzene-1,2-diamine and heated under reflux for 4 hours. After concentration of the reaction liquid, the thus formed residue was purified by a silica gel column chromatography to obtain 2.10 g (39%) of 5-chloro-6-fluoro-2-methyl-1H-benzimidazole from a chloroform-methanol (10:1) eluate. ES+: 185
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709519B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-4cbdda283c24411c97ff68cfbec2cc71 |
| Source note | uspto-grants-2010_05 |