Sulfuryl chloride → Ethyl 2-chloro-4-methoxy-3-oxobutanoate

HRID 2233808Notes

Reaction equation

[CH3:1][O:2][CH2:3][C:4](=[O:11])[CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].S(Cl)([Cl:15])(=O)=O>>[Cl:15][CH:5]([C:4](=[O:11])[CH2:3][O:2][CH3:1])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

Reactant 2

HCID 24648Sulfuryl chloride

HCID 12645099Ethyl 4-methoxy-3-oxobutanoate2×

Product 1

HCID 58007347Ethyl 2-chloro-4-methoxy-3-oxobutanoate

Procedure

The title compound was prepared in a manner analogous to Intermediate 124 starting from ethyl 4-methoxy-3-oxobutanoate (Intermediate 5) and sulfuryl chloride.

Sources & evidence

ORD record: ord-21d37aedebd84f939a591c6326776fd8
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07709503B2

Reaction notes

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