5-methyl-2-formyl-1H-pyrrole-3-carbonitrile → 3-cyano-5-methyl-1H-pyrrole-2-carboxylic acid
Reaction equation
[C:1]([C:3]1[CH:7]=[C:6]([CH2:8]C)[NH:5][C:4]=1[C:10]([OH:12])=[O:11])#[N:2].CC1NC(C=O)=C(C#N)C=1>>[C:1]([C:3]1[CH:7]=[C:6]([CH3:8])[NH:5][C:4]=1[C:10]([OH:12])=[O:11])#[N:2]Participants
3
Procedure
The title compound was prepared by a procedure analogous to Intermediate 31 starting from 5-methyl-2-formyl-1H-pyrrole-3-carbonitrile (preparation: J. Med. Chem. 1998, 41(6) 808-820).
Sources & evidence
- ORD record
- ord-583163801f5b41e38c2264de5796be4a
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07709503B2
Reaction notes
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