Methyl 3-cyano-5-methyl-1H-pyrrole-2-carboxylate → 4-Bromo-3-cyano-5-methyl-1H-pyrrole-2-carboxylic acid

HRID 2233832Notes

Reaction equation

HRID 2233832 reaction equation
[Br:1][C:2]1[C:3]([C:12]#[N:13])=[C:4]([C:9]([OH:11])=[O:10])[NH:5][C:6]=1[CH2:7]C.COC(C1NC(C)=CC=1C#N)=O>>[Br:1][C:2]1[C:3]([C:12]#[N:13])=[C:4]([C:9]([OH:11])=[O:10])[NH:5][C:6]=1[CH3:7]

Participants

3

Reactant 2

HCID 10797098Methyl 3-cyano-5-methyl-1H-pyrrole-2-carboxylate2×HCID 685800054-Bromo-3-cyano-5-ethyl-1H-pyrrole-2-carboxylic acid

Product 1

HCID 580661454-Bromo-3-cyano-5-methyl-1H-pyrrole-2-carboxylic acid

Procedure

The title compound was prepared by a procedure analogous to Intermediate 33 starting from 3-cyano-5-methyl-1H-pyrrole-2-carboxylic acid methyl ester (Intermediate 28).

Sources & evidence

ORD record
ord-5eaf1417fcfe44f18fbfd538b2a12863
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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