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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2233833Generated: October 26, 2026

Sulfuryl chloride → ethyl 2-chloro-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-oxobutanoate

https://huagongshe.com/reaction/2233833

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSulfuryl chlorideHCID 24648—
ReactantEthyl 4-(1,3-dioxoisoindolin-2-YL)-3-oxobutanoateHCID 701239—
Productethyl 2-chloro-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-oxobutanoateHCID 86608257—

Reaction Steps

The title compound was prepared in a manner analogous to Intermediate 124 starting from ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-oxobutanoate (Intermediate 25) and sulfuryl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07709503B2
Source datasetuspto-grants-2010_05
ORD IDord-252466fb7bfd4cd98ff8cd6801963696
Source noteuspto-grants-2010_05