Ethyl 2-chloro-4-methoxy-3-oxobutanoate → Ethyl 2-(4-aminopiperidin-1-yl)-4-(methoxymethyl)-1,3-thiazole-5-carboxylate hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 2-chloro-4-methoxy-3-oxobutanoate	HCID 58007347	—
Reactant	tert-butyl N-(1-carbamothioylpiperidin-4-yl)carbamate	HCID 59296117	—
Product	Ethyl 2-(4-aminopiperidin-1-yl)-4-(methoxymethyl)-1,3-thiazole-5-carboxylate hydrochloride	HCID 68581274	—

Reaction Steps

The title compound was prepared in a manner analogous to Intermediate 126 starting from tert-butyl [1-(aminocarbonothioyl)piperidin-4-yl]carbamate (Intermediate 125) and ethyl 2-chloro-4-methoxy-3-oxobutanoate (Intermediate 6).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07709503B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-dabb03090afb4cf781578ff95f3cb7b9
Source note	uspto-grants-2010_05