4-Chloro-5-methyl-1H-pyrrole-2-carboxylic acid → 4-chloro-5-ethyl-1H-pyrrole-2-carboxylic acid

HRID 2233862Notes

Reaction equation

HRID 2233862 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([O:11]CC)=[O:10])[NH:5][C:6]=1[CH2:7][CH3:8].ClC1C=C(C(O)=O)NC=1C>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([OH:11])=[O:10])[NH:5][C:6]=1[CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 251376814-Chloro-5-methyl-1H-pyrrole-2-carboxylic acidHCID 68580001Ethyl 4-chloro-5-ethyl-1H-pyrrole-2-carboxylate2×

Product 1

HCID 685798254-chloro-5-ethyl-1H-pyrrole-2-carboxylic acid

Procedure

Title compound was synthesized from ethyl 4-chloro-5-ethyl-1H-pyrrole-2-carboxylate (Intermediate 72) by an analogous method to Intermediate 8.

Sources & evidence

ORD record
ord-bcf8f3772a3d486ab3afeb57ee2ae2c6
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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