Ethyl 5-ethyl-1H-pyrrole-2-carboxylate → Ethyl 4-chloro-5-ethyl-1H-pyrrole-2-carboxylate

HRID 2233863Notes

Reaction equation

HRID 2233863 reaction equation
[CH2:1]([C:3]1[NH:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:5][CH:4]=1)[CH3:2].[Cl:13]C1C=C(C(OCC)=O)NC=1C>>[Cl:13][C:4]1[CH:5]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[NH:7][C:3]=1[CH2:1][CH3:2]

Participants

3

Reactant 2

HCID 597485Ethyl 5-ethyl-1H-pyrrole-2-carboxylate2×HCID 66707189ethyl 4-chloro-5-methyl-1H-pyrrole-2-carboxylate

Product 1

HCID 68580001Ethyl 4-chloro-5-ethyl-1H-pyrrole-2-carboxylate

Procedure

Title compound was synthesized from ethyl 5-ethyl-1H-pyrrole-2-carboxylate (Intermediate 12) by an analogous method to Intermediate 9.

Sources & evidence

ORD record
ord-3ee0ddc35c724d3ea9ae0ab88ee4c6da
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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