4-Chloro-5-methyl-1H-pyrrole-2-carboxylic acid → 3,4-Dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid

HRID 2233864Notes

Reaction equation

HRID 2233864 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH2:8][CH3:9])[NH:4][C:3]=1[C:10]([O:12]CC)=[O:11].ClC1C=C(C(O)=O)NC=1C>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH2:8][CH3:9])[NH:4][C:3]=1[C:10]([OH:12])=[O:11]

Participants

3

Reactant 2

HCID 251376814-Chloro-5-methyl-1H-pyrrole-2-carboxylic acidHCID 68579980ethyl 3,4-dichloro-5-ethyl-1H-pyrrole-2-carboxylate2×

Product 1

HCID 685797083,4-Dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid

Procedure

Title compound was synthesized from ethyl 3,4-dichloro-5-ethyl-1H-pyrrole-2-carboxylate (Intermediate 74) by an analogous method to Intermediate 8.

Sources & evidence

ORD record
ord-61327f32c1d04a22ac6ae1608bd9ac57
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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