1H-Pyrrole-2-carboxylic acid, 4-chloro-3,5-dimethyl, ethyl ester → 4-Chloro-3,5-dimethyl-1H-pyrrole-2-carboxylic acid

HRID 2233866Notes

Reaction equation

HRID 2233866 reaction equation
[Cl:1][C:2]1[C:3]([CH3:13])=[C:4]([C:8]([O:10]CC)=[O:9])[NH:5][C:6]=1[CH3:7].ClC1C=C(C(O)=O)NC=1C>>[Cl:1][C:2]1[C:3]([CH3:13])=[C:4]([C:8]([OH:10])=[O:9])[NH:5][C:6]=1[CH3:7]

Participants

3

Reactant 2

HCID 1435841H-Pyrrole-2-carboxylic acid, 4-chloro-3,5-dimethyl, ethyl ester2×HCID 251376814-Chloro-5-methyl-1H-pyrrole-2-carboxylic acid

Product 1

HCID 594068974-Chloro-3,5-dimethyl-1H-pyrrole-2-carboxylic acid

Procedure

Title compound was synthesized from ethyl 4-chloro-3,5-dimethyl-1H-pyrrole-2-carboxylate (Intermediate 76) by an analogous method to Intermediate 8.

Sources & evidence

ORD record
ord-e1849c6fbfa44007a2d546c6f0c32b28
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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