tert-butyl N-(1-carbamothioylpiperidin-4-yl)carbamate → Ethyl 2-(4-aminopiperidin-1-yl)-4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1,3-thiazole-5-carboxylate hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	tert-butyl N-(1-carbamothioylpiperidin-4-yl)carbamate	HCID 59296117	—
Reactant	ethyl 2-chloro-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-oxobutanoate	HCID 86608257	—
Product	Ethyl 2-(4-aminopiperidin-1-yl)-4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1,3-thiazole-5-carboxylate hydrochloride	HCID 68579924	—

Reaction Steps

The title compound was prepared in a manner analogous to Intermediate 126 starting from tert-butyl [1-(aminocarbonothioyl)piperidin-4-yl]carbamate (Intermediate 125) and ethyl 2-chloro-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-oxobutanoate (Intermediate 35).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07709503B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-1bb41547ebe549769fc4029f17c45a98
Source note	uspto-grants-2010_05