4-(N-Boc-amino)piperidine → HCID 68582510, compound

HRID 2233870Notes

Reaction equation

HRID 2233870 reaction equation
[N+](C1C(N2CCC(NC(=O)OC(C)(C)C)CC2)=NC=CC=1)([O-])=O.[NH:24]1[CH2:29][CH2:28][CH:27]([NH:30][C:31](=[O:37])[O:32][C:33]([CH3:36])([CH3:35])[CH3:34])[CH2:26][CH2:25]1.Br[C:39]1[S:40][C:41]([C:44]([NH2:46])=[O:45])=[CH:42][N:43]=1>>[NH2:46][C:44]([C:41]1[S:40][C:39]([N:24]2[CH2:25][CH2:26][CH:27]([NH:30][C:31](=[O:37])[O:32][C:33]([CH3:34])([CH3:36])[CH3:35])[CH2:28][CH2:29]2)=[N:43][CH:42]=1)=[O:45]

Participants

4

Reactant 3

HCID 7238334-(N-Boc-amino)piperidineHCID 203286042-Bromo-1,3-thiazole-5-carboxamideHCID 44120582HCID 44120582, compound

Product 1

HCID 68582510HCID 68582510, compound

Procedure

Title compound was synthesized by an analogous method to Intermediate 38 by coupling tert-butyl piperidin-4-ylcarbamate (commercially available) with 2-bromo-1,3-thiazole-5-carboxamide (J. Am. Chem. Soc. 1952, 74, 5799).

Sources & evidence

ORD record
ord-3d1f4085fdb14cf5b2c6d9e26dafc5c4
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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