HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,6-dichloroisonicotinate → Methyl 2-chloro-6-(methylthio)isonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,6-dichloroisonicotinate | HCID 93237 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 2-chloro-6-(methylthio)isonicotinate | HCID 86038391 | 93.1% |
Reaction Steps
Methyl 2,6-dichloroisonicotinate (300 mg, 1.45 mmol) was dissolved in anhydrous DMF. Sodium thiomethoxide (102 mg, 1.45 mmol) was added and the mixture was stirred at room temperature for 4 h. The mixture was diluted with EtOAc and washed with water (×3), brine (×1) and dried over sodium sulfate and concentrated in vacuo to afford title compound (294 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-807917121d6d4000a128ea542c0d8f8e |
| Source note | uspto-grants-2010_05 |