Sodium Carbonate → HCID 11514618, compound

HRID 2233877Notes

Reaction equation

HRID 2233877 reaction equation
FC(F)(F)C([O-])=O.[Cl:8][C:9]1[C:13]([Cl:14])=[C:12]([CH3:15])[NH:11][C:10]=1[C:16]([NH:18][CH:19]1[CH2:24][CH2:23][NH2+:22][CH2:21][CH2:20]1)=[O:17].C(Cl)(Cl)Cl.C(O)(C)C.C([O-])([O-])=O.[Na+].[Na+]>O>[Cl:8][C:9]1[C:13]([Cl:14])=[C:12]([CH3:15])[NH:11][C:10]=1[C:16]([NH:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:17]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 21906603Chloroform isopropyl alcoholHCID 685798674-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidinium trifluoroacetate2×

Product 1

HCID 11514618HCID 11514618, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidinium trifluoroacetate (Intermediate 86, 6.07 g) was suspended in water (100 ml). To this was added 100 ml of CHCl3:isopropanol (3:1) and sat. Na2CO3 (50 ml). The organic portion was separated and the aqueous portion was washed with 100 ml portions of CHCl3:isopropanol (3:1) five times. The organic portions were combined, dried with MgSO4 and concentrated to a yellow solid (2.73 g, 64%).

Workup

  1. customThe organic portion was separated
  2. washthe aqueous portion was washed with 100 ml portions of CHCl3:isopropanol (3:1) five times
  3. dry with materialdried with MgSO4
  4. concentrationconcentrated to a yellow solid (2.73 g, 64%)

Sources & evidence

ORD record
ord-e4816458b7694eb78f271fce39dbb9d1
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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