反应详情

4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidinium trifluoroacetate (Intermediate 86, 6.07 g) was suspended in water (100 ml). To this was added 100 ml of CHCl3:isopropanol (3:1) and sat. Na2CO3 (50 ml). The organic portion was separated and the aqueous portion was washed with 100 ml portions of CHCl3:isopropanol (3:1) five times. The organic portions were combined, dried with MgSO4 and concentrated to a yellow solid (2.73 g, 64%).

1. customThe organic portion was separated
2. washthe aqueous portion was washed with 100 ml portions of CHCl3:isopropanol (3:1) five times
3. dry with materialdried with MgSO4
4. concentrationconcentrated to a yellow solid (2.73 g, 64%)