HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → Ethyl 2-chloro-4-(2-methoxyethoxy)-3-oxobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Butanoic acid, 4-(2-methoxyethoxy)-3-oxo-, ethyl ester | HCID 2759572 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl 2-chloro-4-(2-methoxyethoxy)-3-oxobutanoate | HCID 86038328 | 70.8% |
Reaction Steps
Ethyl 4-(2-methoxyethoxy)-3-oxobutanoate (Intermediate 123) (0.5 g) was dissolved in anhydrous DCM (5 ml). Sulfuryl chloride (430 mg) was added dropwise at room temperature. The mixture was stirred for 6 h. The crude mixture was diluted with EtOAc (50 ml) and washed well with water and brine, dried over sodium sulfate and concentrated in vacuo to afford the title compound as a light orange oil (414 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-339bde1c8c6b42179d06964ffd5121b5 |
| Source note | uspto-grants-2010_05 |