反应详情

tert-Butyl piperidin-4-ylcarbamate (5.5 g) was dissolved in anhydrous DCM (75 ml). H-Fluoren-9-ylmethyl isothiocyanatidocarbonate (Fmoc isothiocyanate; 7.75 g) was added in small portions at room temperature after which time a white precipitate formed. The mixture was stirred at room temperature for 90 min. The solvent was removed in vacuo and the crude mixture was treated with 10% piperidine in MeOH (100 ml) for 12 h. The mixture was concentrated in vacuo and triturated with n-hexanes. The white crystalline material was filtered and washed well with n-hexanes and dried in vacuo to afford the title compound (6.55 g).

1. additionwas added in small portions at room temperature after which time a white precipitate
2. customformed
3. customThe solvent was removed in vacuo
4. additionthe crude mixture was treated with 10% piperidine in MeOH (100 ml) for 12 h
5. concentrationThe mixture was concentrated in vacuo
6. customtriturated with n-hexanes
7. filtrationThe white crystalline material was filtered
8. washwashed well with n-hexanes
9. customdried in vacuo