HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2,3-dihydro-7-methoxy-8-[4-(4-phenyl-1-piperazinyl)butyloxy]cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 2,3-dihydro-8-[4-(methanesulfonyloxy)butyloxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one | HCID 19927634 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2,3-dihydro-7-methoxy-8-[4-(4-phenyl-1-piperazinyl)butyloxy]cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927642 | 55% |
Reaction Steps
Method B (16 h at 80° C.); starting materials: 2,3-dihydro-8-[4-(methanesulfonyloxy)butyloxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one (example 84) and 1-phenylpiperazine; yield 55%; fusion point 162°-165° C. (from ethanol). Fumarate: method E; yield 95%; fusion point 179°-183° C. (from acetone).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-96490beb0f534cc89f51d29988f58252 |
| Source note | uspto-grants-1995_06 |