Thionyl Chloride → 3,4-Dichloro-5-methyl-1H-pyrrole-2-carbonyl chloride

HRID 2233906Notes

Reaction equation

HRID 2233906 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([OH:11])=O.O=S(Cl)[Cl:14]>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([Cl:14])=[O:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 251376823,4-Dichloro-5-methyl-1H-pyrrole-2-carboxylic acid2×

Product 1

HCID 860383943,4-Dichloro-5-methyl-1H-pyrrole-2-carbonyl chloride

Procedure

A solution of 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3) in 50 ml SOCl2 was heated at reflux for 30 min. Solvent was removed and the residue was dried in vacuo.

Workup

  1. temperatureat reflux for 30 min
  2. customSolvent was removed
  3. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-4b249a061e424d73ad4af16dd14045bf
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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