4-Chloro-3,5-dimethyl-1H-pyrrole-2-carboxylic acid → 2-Chloro-6-(4-{[(4-chloro-3,5-dimethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide
Reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([Cl:18])[N:17]=2)[C:12]([NH2:14])=[O:13])[CH2:5][CH2:4]1.[Cl:19][C:20]1[C:21]([CH3:29])=[C:22]([C:26](O)=[O:27])[NH:23][C:24]=1[CH3:25]>>[Cl:18][C:16]1[CH:15]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:26]([C:22]3[NH:23][C:24]([CH3:25])=[C:20]([Cl:19])[C:21]=3[CH3:29])=[O:27])[CH2:8][CH2:7]2)[N:17]=1)[C:12]([NH2:14])=[O:13]Participants
3
Procedure
Title compound was synthesized by an analogous method to Example 18 by coupling 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride (Intermediate 70) with 4-chloro-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (Intermediate 75).
Sources & evidence
- ORD record
- ord-dd04c02d706f40b79cbf3d77a12940c2
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07709503B2
Reaction notes
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