4-cyano-3,5-dimethyl-1H-pyrrole-2-carboxylic acid → HCID 86608277, compound

HRID 2233925Notes

Reaction equation

HRID 2233925 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([Cl:18])[N:17]=2)[C:12]([NH2:14])=[O:13])[CH2:5][CH2:4]1.[C:19]([C:21]1[C:22]([CH3:30])=[C:23]([C:27](O)=[O:28])[NH:24][C:25]=1[CH3:26])#[N:20]>>[Cl:18][C:16]1[CH:15]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:27]([C:23]3[NH:24][C:25]([CH3:26])=[C:21]([C:19]#[N:20])[C:22]=3[CH3:30])=[O:28])[CH2:8][CH2:7]2)[N:17]=1)[C:12]([NH2:14])=[O:13]

Participants

3

Reactant 2

HCID 7593034-cyano-3,5-dimethyl-1H-pyrrole-2-carboxylic acidHCID 86608255HCID 86608255, compound2×

Product 1

HCID 86608277HCID 86608277, compound

Procedure

Title compound was synthesized by an analogous method to Example 18 by coupling 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride (Intermediate 70) with 4-cyano-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (commercially available).

Sources & evidence

ORD record
ord-48d43a0c0e6e431094c0426b3795fd59
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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