Ammonia → HCID 86608282, compound

HRID 2233931Notes

Reaction equation

HRID 2233931 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[C:21]([Cl:23])[N:20]=[C:19]([C:24]([OH:26])=O)[CH:18]=3)[CH2:13][CH2:12]2)=[O:9])[NH:5][C:6]=1[CH3:7].[NH3:27]>CO>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][CH:11]2[CH2:12][CH2:13][N:14]([C:17]3[N:22]=[C:21]([Cl:23])[N:20]=[C:19]([C:24]([NH2:27])=[O:26])[CH:18]=3)[CH2:15][CH2:16]2)=[O:9])[NH:5][C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86608278HCID 86608278, compound

Product 1

HCID 86608282HCID 86608282, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Title compound was synthesized by an analogous method to Example 8 by coupling 6-(4-{[(4-bromo-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-chloropyrimidine-4-carboxylic acid (Example 31) with 2 M ammonia in MeOH.

Sources & evidence

ORD record
ord-7ff8228b5caa404b8c6415d4510af63c
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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