Ammonia → HCID 86608283, compound

HRID 2233932Notes

Reaction equation

HRID 2233932 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[C:4]([N:11]2[CH2:16][CH2:15][CH:14]([NH:17][C:18]([C:20]3[NH:21][C:22]([CH3:27])=[C:23]([Cl:26])[C:24]=3[Cl:25])=[O:19])[CH2:13][CH2:12]2)[N:3]=1.[NH3:28]>CO>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH2:28])=[O:10])[CH:5]=[C:4]([N:11]2[CH2:16][CH2:15][CH:14]([NH:17][C:18]([C:20]3[NH:21][C:22]([CH3:27])=[C:23]([Cl:26])[C:24]=3[Cl:25])=[O:19])[CH2:13][CH2:12]2)[N:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86608267HCID 86608267, compound

Product 1

HCID 86608283HCID 86608283, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Title compound was synthesized by an analogous method to Example 8 by coupling 2-chloro-6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)pyrimidine-4-carboxylic acid (Example 32) with 2 M ammonia in MeOH.

Sources & evidence

ORD record
ord-8b0dcae38b3b4b32836020b6f909f02c
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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