Ammonia → HCID 68579927, compound

HRID 2233933Notes

Reaction equation

HRID 2233933 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[C:21]([S:23][CH3:24])[N:20]=[C:19]([C:25](O)=[O:26])[CH:18]=3)[CH2:13][CH2:12]2)=[O:9])[NH:5][C:6]=1[CH3:7].[NH3:28]>CO>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[C:21]([S:23][CH3:24])[N:20]=[C:19]([C:25]([NH2:28])=[O:26])[CH:18]=3)[CH2:13][CH2:12]2)=[O:9])[NH:5][C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68579906HCID 68579906, compound

Product 1

HCID 68579927HCID 68579927, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Title compound was synthesized by an analogous method to Example 8 by coupling 6-(4-{[(4-bromo-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-(methylthio) pyrimidine-4-carboxylic acid (Example 35) with 2 M ammonia in MeOH (commercially available).

Sources & evidence

ORD record
ord-e3ddb09bca8c41269ae23d40de6151f7
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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