HCID 86608297, compound → HCID 86608296, compound

HRID 2233948Notes

Reaction equation

HRID 2233948 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:23]=[C:24]([Cl:26])[N:25]=2)[C:12]([NH:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[O:13])[CH2:5][CH2:4]1.[Cl:27][C:28]1[C:32]([Cl:33])=[C:31]([CH3:34])[NH:30][C:29]=1[C:35](NC1CCN(C2C=CC=C(Cl)N=2)CC1)=[O:36]>>[Cl:26][C:24]1[CH:23]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:35]([C:29]3[NH:30][C:31]([CH3:34])=[C:32]([Cl:33])[C:28]=3[Cl:27])=[O:36])[CH2:8][CH2:7]2)[N:25]=1)[C:12]([NH:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)=[O:13]

Participants

3

Reactant 2

HCID 86608297HCID 86608297, compound2×HCID 86608299HCID 86608299, compound2×

Product 1

HCID 86608296HCID 86608296, compound

Procedure

The title compound was synthesised by an analogous method to Example 18 from 2-(4-aminopiperidin-1-yl)-6-chloro-N-(2-morpholin-4-ylethyl)isonicotinamide hydrochloride salt (Intermediate 218) and 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3).

Sources & evidence

ORD record
ord-d1e3898978534917873f6c08eb89a16b
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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