HCID 86608299, compound → HCID 86608300, compound

HRID 2233949Notes

Reaction equation

HRID 2233949 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:24]=[C:25]([Cl:27])[N:26]=2)[C:12]([NH:14][CH2:15][CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[O:13])[CH2:5][CH2:4]1.[Cl:28][C:29]1[C:33]([Cl:34])=[C:32]([CH3:35])[NH:31][C:30]=1[C:36](NC1CCN(C2C=CC=C(Cl)N=2)CC1)=[O:37]>>[Cl:27][C:25]1[CH:24]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:36]([C:30]3[NH:31][C:32]([CH3:35])=[C:33]([Cl:34])[C:29]=3[Cl:28])=[O:37])[CH2:8][CH2:7]2)[N:26]=1)[C:12]([NH:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)=[O:13]

Participants

3

Reactant 2

HCID 86608299HCID 86608299, compound2×HCID 86608301HCID 86608301, compound2×

Product 1

HCID 86608300HCID 86608300, compound

Procedure

The title compound was synthesised by an analogous method to Example 99 starting from 2-(4-aminopiperidin-1-yl)-6-chloro-N-(3-morpholin-4-ylpropyl)isonicotinamide hydrochloride salt (Intermediate 219) and 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3).

Sources & evidence

ORD record
ord-be696903f6d24225b44925232bc9824d
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

Loading…