HCID 68579970, compound → HCID 68580180, compound

HRID 2233951Notes

Reaction equation

HRID 2233951 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([C:18]#[N:19])[N:17]=2)[C:12]([NH2:14])=[O:13])[CH2:5][CH2:4]1.[Cl:20][C:21]1[C:25]([Cl:26])=[C:24]([CH3:27])[NH:23][C:22]=1[C:28](NC1CCN(C2C=C(SCC(NC)=O)C=C(Cl)N=2)CC1)=[O:29]>>[C:18]([C:16]1[CH:15]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:28]([C:22]3[NH:23][C:24]([CH3:27])=[C:25]([Cl:26])[C:21]=3[Cl:20])=[O:29])[CH2:8][CH2:7]2)[N:17]=1)[C:12]([NH2:14])=[O:13])#[N:19]

Participants

3

Reactant 2

HCID 68579970HCID 68579970, compound2×HCID 86608306HCID 86608306, compound2×

Product 1

HCID 68580180HCID 68580180, compound

Procedure

The title compound was synthesised by an analogous method to Example 18 starting from 2-(4-aminopiperidin-1-yl)-6-cyanoisonicotinamide hydrochloride salt (Intermediate 198) and 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3).

Sources & evidence

ORD record
ord-fdda93a079f94764ab1aacdd88b87228
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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