N-[6-(4-aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-yl]acetamide hydrochloride → N-{1-[6-(Acetylamino)-2-(methylsulfanyl)-4-pyrimidinyl]-4-piperidinyl}-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	N-[6-(4-aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-yl]acetamide hydrochloride	HCID 68582443	—
Reactant	3,4-Dichloro-N-{1-[6-chloro-4-(1,2,4-oxadiazol-3-yl)-2-pyridinyl]-4-piperidinyl}-5-methyl-1H-pyrrole-2-carboxamide	HCID 86608316	—
Product	N-{1-[6-(Acetylamino)-2-(methylsulfanyl)-4-pyrimidinyl]-4-piperidinyl}-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide	HCID 68580101	—

Reaction Steps

The title compound was synthesised by an analogous method to Example 118 starting from N-[6-(4-aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-yl]acetamide hydrochloride (Intermediate 69) and 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07709503B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-887a8748e7054afb9c3d985fa6012819
Source note	uspto-grants-2010_05