HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1,3-thiazole-5-carbonitrile → 4-bromo-N-[1-(5-cyano-1,3-thiazol-2-yl)piperidin-4-yl]-5-methyl-1H-pyrrole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1,3-thiazole-5-carbonitrile | HCID 17860952 | — |
| Reactant | HCID 68579819 | HCID 68579819 | — |
| Product | 4-bromo-N-[1-(5-cyano-1,3-thiazol-2-yl)piperidin-4-yl]-5-methyl-1H-pyrrole-2-carboxamide | HCID 68582663 | — |
Reaction Steps
Title compound was synthesized by an analogous method to Example 123 by coupling 4-bromo-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 57) with 2-bromo-1,3-thiazole-5-carbonitrile (Tetrahedron Lett. 1977, 21, 1813).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-c41f8cfb2f134349a8b778b68e43a31d |
| Source note | uspto-grants-2010_05 |