Pentafluorophenyl 4-bromo-5-methyl-1H-pyrrole-2-carboxylate → HCID 178433658, compound

HRID 2233973Notes

Reaction equation

HRID 2233973 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14][CH3:15])[CH2:10][CH2:9]2)[CH:5]=[C:4]([C:16]2[NH:20][N:19]=[N:18][N:17]=2)[CH:3]=1.[Br:21][C:22]1[CH:23]=[C:24]([C:28]([O:30]C2C(F)=C(F)C(F)=C(F)C=2F)=O)[NH:25][C:26]=1[CH3:27]>>[Br:21][C:22]1[CH:23]=[C:24]([C:28]([N:14]([CH:11]2[CH2:10][CH2:9][N:8]([C:6]3[CH:5]=[C:4]([C:16]4[NH:20][N:19]=[N:18][N:17]=4)[CH:3]=[C:2]([Cl:1])[N:7]=3)[CH2:13][CH2:12]2)[CH3:15])=[O:30])[NH:25][C:26]=1[CH3:27]

Participants

3

Reactant 2

HCID 86608241Pentafluorophenyl 4-bromo-5-methyl-1H-pyrrole-2-carboxylate2×HCID 178482247HCID 178482247, compound2×

Product 1

HCID 178433658HCID 178433658, compound

Procedure

The title compound was synthesised by an analogous method to Example 18 starting from 1-[6-chloro-4-(1H-tetrazol-5-yl)pyridin-2-yl]-N-methylpiperidin-4-amine (Intermediate 64) and pentafluorophenyl 4-bromo-5-methyl-1H-pyrrole-2-carboxylate (Intermediate 17).

Sources & evidence

ORD record
ord-9e36723b2b54446791234f21d49a2e9c
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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