Trifluoroacetic acid → HCID 86608324, compound

Participants

Reaction Conditions

Reaction Steps

6-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-N-methoxypyrimidine-4-carboxamide (Example 313; 0.60 g, 1.08 mmol) was dissolved in THF/water (4:1; 2.5 ml) and cooled to 0° C. TFA (0.1 ml) was added to the solution which was then slowly warmed to room temperature and stirred overnight. The mixture was neutralized with concentrated ammonium hydroxide and the THF was removed in vacuo. The mixture was diluted with water (4 ml), extracted with DCM, and the organic layers dried over magnesium sulfate. The mixture was concentrated in vacuo and crude product was purified by reverse phase chromatography eluting with acetonitrile/water (0.1% TFA) (33 mg).

Provenance & Evidence