Sodium Sulfite → HCID 86608326, compound

Participants

Reaction Steps

6-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-N-methoxy-2-[2-(methylthio)ethoxy]pyrimidine-4-carboxamide (Example 165, 0.10 g, 0.19 mmol) was suspended in DCM (5 ml) and cooled to 0° C. mCPBA (0.067 g, 0.387 mmol, 70%) was added, then the reaction was warmed to room temperature and stirred for 4 h. A further equivalent of mCPBA was added and the mixture was stirred overnight. A solution of sodium sulfite (5%, 3 ml) was added and the layers separated. The aqueous phase was extracted with EtOAc and the combined organic extract was dried over magnesium sulfate and concentrated to give a white solid which was purified by reverse phase chromatography eluting with (20% to 75% acetonitrile in water, 0.1% TFA) affording the title compound (44 mg).

Provenance & Evidence