HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → HCID 68580089, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | HCID 68579762 | HCID 68579762 | — |
| Reactant | HCID 68579911 | HCID 68579911 | — |
| Reactant | 2-(4-Aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride | HCID 86608255 | — |
| Reactant | HCID 86608334 | HCID 86608334 | — |
| Product | HCID 68580089 | HCID 68580089 | — |
Reaction Steps
(6-{4-[(tert-Butoxycarbonyl)amino]piperidin-1-yl}-2-butylpyrimidine-4-carboxylic acid) (Intermediate 100) was treated with 4 N HCl/dioxane for as described for Intermediate 70. The resulting hydrochloride salt, 6-(4-aminopiperidin-1-yl)-2-butylpyrimidine-4-carboxylic acid hydrochloride salt was coupled to 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3) in a manner analogous to Example 29 to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-0b298626a44f4b319458d740fd731216 |
| Source note | uspto-grants-2010_05 |