Acetonitrile → HCID 68582659, compound

Participants

Reaction Steps

5-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3,4-thiadiazole-2-carboxylic acid (Example 223; 0.250 g, 0.60 mmol) was stirred in 10 mM ammonium acetate (pH 8) (15 ml) and acetonitrile (15 ml) overnight. The mixture was concentrated then the residue was stirred in acetonitrile and filtered. The solid was dissolved in DMSO and purified using semi-preparative HPLC (10% ammonium acetate:water/acetonitrile (20:80-95:5)) to give the title compound as a white solid (0.092 g).

Provenance & Evidence