HuagongsheHuagongshe Chemistry Print Report · For research reference only
LiOH THF → 2-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-4-[(2-methoxyethoxy)methyl]-1,3-thiazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | LiOH THF | HCID 67059675 | — |
| Reactant | Ethyl 2-(4-aminopiperidin-1-yl)-4-[(2-methoxyethoxy)methyl]-1,3-thiazole-5-carboxylate hydrochloride | HCID 68579915 | — |
| Reactant | HCID 178433654 | HCID 178433654 | — |
| Product | 2-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-4-[(2-methoxyethoxy)methyl]-1,3-thiazole-5-carboxylic acid | HCID 68579711 | — |
Reaction Steps
Prepared in an analogous manner to Example 129 starting from ethyl 2-(4-aminopiperidin-1-yl)-4-[(2-methoxyethoxy)methyl]-1,3-thiazole-5-carboxylate hydrochloride (Intermediate 126) and 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3). The ester product was submitted to hydrolysis using LiOH/THF at 65° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-256b3800db2e4e91916e86c6e50ef883 |
| Source note | uspto-grants-2010_05 |