Potassium Permanganate → HCID 68579982, compound

Participants

Reaction Steps

Solutions of 3,4-dichloro-N-[1-(3-formyl-1H-pyrrol-1-yl)piperidin-4-yl]-5-methyl-1H-pyrrole-2-carboxamide (Example 259, 90 mg, 0.24 mmol) in 10 ml acetone and KMNO4 (39 mg, 0.24 mmol) in 3 ml water were combined and stirred at ambient temperature overnight. Due to incomplete conversion, solutions of KMnO4 (15 and 20 mg) in 3 ml water were added at 5 hour intervals. The mixture was quenched with aqueous NaHSO3 and partitioned between EtOAc and water. The EtOAc was separated and washed with brine. Drying (MgSO4) and removal of solvent gave product as a white solid.

Provenance & Evidence