HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ethyl 4-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)quinazoline-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 4-chloroquinazoline-2-carboxylate | HCID 3477840 | — |
| Reactant | 4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidinium trifluoroacetate | HCID 68579867 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | Ethyl 4-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)quinazoline-2-carboxylate | HCID 68579939 | 47.7% |
Reaction Steps
As described for the synthesis of Example 264, ethyl 4-chloroquinazoline-2-carboxylate (690 mg), 4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidinium trifluoroacetate (Intermediate 86; 1.7 g), and K2CO3 (1.7 g) in 20 ml tert-butanol were combined to yield 662 mg grey solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-01f394cbedb1429687c49825429b4852 |
| Source note | uspto-grants-2010_05 |