HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2234027Generated: October 31, 2026
Tert-butyl 2-chloro-2-cyanoacetate → 3,4-dichloro-N-[1-(5-cyano-4-methoxy-1,3-thiazol-2-yl)piperidin-4-yl]-5-methyl-1H-pyrrole-2-carboxamide
https://huagongshe.com/reaction/2234027
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tert-butyl 2-chloro-2-cyanoacetate | HCID 13257235 | — |
| Reactant | N-[1-(Aminocarbonothioyl)piperidin-4-yl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide | HCID 86608262 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3,4-dichloro-N-[1-(5-cyano-4-methoxy-1,3-thiazol-2-yl)piperidin-4-yl]-5-methyl-1H-pyrrole-2-carboxamide | HCID 68579932 | — |
Reaction Steps
A suspension of N-[1-(aminocarbonothioyl)piperidin-4-yl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide (Intermediate 95, 0.22 g, 0.7 mmol) and tert-butyl chloro(cyano)acetate (0.12 g, 0.7 mmol) in MeOH was heated to 80° C. in the microwave reactor for 40 minutes. The product precipitated and was filtered off.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07709503B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-00a0fa6357f8468e89f78b6bf36bd028 |
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| Source note | uspto-grants-2010_05 |
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