反应详情

Iodotrimethylsilane (0.02 ml, 0.13 mmol) was added to a suspension of 3,4-dichloro-N-[1-(5-cyano-4-methoxy-1,3-thiazol-2-yl)piperidin-4-yl]-5-methyl-1H-pyrrole-2-carboxamide (Example 269, 0.04 g, 0.1 mmol) in DCM:CHCl3 (1:1). After stirring for one hour the reaction was complete. Partitioning with EtOAc and water, drying organic portion with MgSO4 and concentrating yielded a yellow oil which, after triturating with ether, gave a yellow solid.

1. customPartitioning with EtOAc and water
2. dry with materialdrying organic portion with MgSO4
3. concentrationconcentrating
4. customyielded a yellow oil which
5. customafter triturating with ether
6. customgave a yellow solid