Sodium Hydroxide → 52934-83-5

HRID 223403Notes

Reaction equation

[CH3:1][C@@H:2]1[O:19][C@@H:18]([CH2:20][C:21]([OH:23])=[O:22])[CH2:17][C@@:15]23O[C@@:3]12[C:4]([C:6]1[C:11]([OH:12])=[CH:10][CH:9]=[CH:8][C:7]=1[C:13]3=[O:14])=[O:5].[OH-].[Na+]>>[CH3:1][CH:2]1[O:19][CH:18]([CH2:20][C:21]([OH:23])=[O:22])[CH2:17][C:15]2[C:13]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]([OH:12])[C:6]=3[C:4](=[O:5])[C:3]1=2)=[O:14]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 175109Nanaomycin E

Product 1

HCID 4058652934-83-5

Procedure

An aqueous solution of nanaomycin E (200 μg/ml) prepared in Example 1 was adjusted to a pH of 10 with addition of caustic soda. A reducing agent was added to the solution at a concentration of 3% by weight/volume, and the solution was kept at a temperature of 50° C. The change of the concentration of nanaomycin A formed in the solution was determined with the lapse of time. The production yield was determined at the end of the reaction. The results are shown in Table 1.

Workup

additionA reducing agent was added to the solution at a concentration of 3% by weight/volume
customwas kept at a temperature of 50° C

Sources & evidence

ORD record: ord-677cd65edabd44a89c08e493baeb9583
Source dataset: uspto-grants-1982_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04353986

Reaction notes

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