methyl 2-chloro-6-methoxypyrimidine-4-carboxylate → HCID 68579853, compound

HRID 2234046Notes

Reaction equation

HRID 2234046 reaction equation
Cl.[Cl:2][C:3]1[C:7]([Cl:8])=[C:6]([CH3:9])[NH:5][C:4]=1[C:10]([NH:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:11].Cl[C:20]1[N:25]=[C:24]([C:26]([O:28][CH3:29])=[O:27])[CH:23]=[C:22]([O:30][CH3:31])[N:21]=1>>[Cl:2][C:3]1[C:7]([Cl:8])=[C:6]([CH3:9])[NH:5][C:4]=1[C:10]([NH:12][CH:13]1[CH2:18][CH2:17][N:16]([C:20]2[N:25]=[C:24]([C:26]([O:28][CH3:29])=[O:27])[CH:23]=[C:22]([O:30][CH3:31])[N:21]=2)[CH2:15][CH2:14]1)=[O:11]

Participants

3

Reactant 2

HCID 312614methyl 2-chloro-6-methoxypyrimidine-4-carboxylate2×HCID 68579996HCID 68579996, compound2×

Product 1

HCID 68579853HCID 68579853, compound

Procedure

The title compound was synthesized by an analogous method to Example 6 starting from 3,4-dichloro-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 1) and methyl 2-chloro-6-methoxypyrimidine-4-carboxylate (Intermediate 88).

Sources & evidence

ORD record
ord-e0061404fff84de6bf2ff27fc836bfe0
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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