HCID 68579940, compound → Methyl 2-chloro-6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinate

HRID 2234052Notes

Reaction equation

HRID 2234052 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9](NC1CCN(C2SC=CN=2)CC1)=[O:10].Cl.[NH2:24][CH:25]1[CH2:30][CH2:29][N:28]([C:31]2[CH:32]=[C:33]([CH:38]=[C:39]([Cl:41])[N:40]=2)[C:34]([O:36][CH3:37])=[O:35])[CH2:27][CH2:26]1>>[Cl:41][C:39]1[CH:38]=[C:33]([CH:32]=[C:31]([N:28]2[CH2:27][CH2:26][CH:25]([NH:24][C:9]([C:3]3[NH:4][C:5]([CH3:8])=[C:6]([Cl:7])[C:2]=3[Cl:1])=[O:10])[CH2:30][CH2:29]2)[N:40]=1)[C:34]([O:36][CH3:37])=[O:35]

Participants

3

Reactant 2

HCID 68579940HCID 68579940, compound2×HCID 86608260Methyl 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinate hydrochloride salt2×

Product 1

HCID 86608321Methyl 2-chloro-6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinate

Procedure

The title compound was prepared in a manner analogous to Example 18 starting from 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3) and methyl 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinate hydrochloride salt (Intermediate 93).

Sources & evidence

ORD record
ord-504fe7ad21194b0ba9d7fe725257368e
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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