HCID 68579940, compound → 6-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-pyrrolidin-1-ylpyrimidine-4-carboxylic acid

HRID 2234054Notes

Reaction equation

HRID 2234054 reaction equation
ClC1C(Cl)=C(C)NC=1C(NC1CCN(C2SC=CN=2)CC1)=O.[Cl:23][C:24]1[C:28]([Cl:29])=[C:27]([CH3:30])[NH:26][C:25]=1[C:31]([NH:33][CH:34]1[CH2:39][CH2:38][N:37]([C:40]2[N:45]=[C:44]([N:46]3[CH2:50][CH2:49][CH2:48][CH2:47]3)[N:43]=[C:42]([C:51]([O:53]C)=[O:52])[CH:41]=2)[CH2:36][CH2:35]1)=[O:32]>>[Cl:23][C:24]1[C:28]([Cl:29])=[C:27]([CH3:30])[NH:26][C:25]=1[C:31]([NH:33][CH:34]1[CH2:39][CH2:38][N:37]([C:40]2[N:45]=[C:44]([N:46]3[CH2:50][CH2:49][CH2:48][CH2:47]3)[N:43]=[C:42]([C:51]([OH:53])=[O:52])[CH:41]=2)[CH2:36][CH2:35]1)=[O:32]

Participants

3

Reactant 2

HCID 68579940HCID 68579940, compoundHCID 68579942Methyl 6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-pyrrolidin-1-ylpyrimidine-4-carboxylate

Product 1

HCID 685826546-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-pyrrolidin-1-ylpyrimidine-4-carboxylic acid

Procedure

The title compound was synthesized by an analogous method to Intermediate 3 starting from methyl 6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-pyrrolidin-1-ylpyrimidine-4-carboxylate (Example 316).

Sources & evidence

ORD record
ord-8fb32921339b410ca62e37c10cf2d535
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

Loading…