HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2234063Generated: October 30, 2026
Hydrochloric Acid → 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one
https://huagongshe.com/reaction/2234063
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(3-Methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester | HCID 67148857 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one | HCID 135687553 | 25.1% |
Reaction Steps
25 mg of 2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester, 7.4 mg trimethylchlorosilane and 11.3 mg KI dissolved in 1 ml of acetonitril are stirred for 2 h at 60° C. Subsequently 0.5 ml of a 4N solution of hydrochloric acid in dioxane is added and stirred for 2 h at room temperature. The solution is diluted into DMF (dimethylformamide)/water and directly purified by HPLC (high performance liquid chromatography) on a RP18 (reversed phase 18) column giving 4.5 mg 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07709466B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-0fbaf4121e4b42eeb93af6374fba7dde |
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| Source note | uspto-grants-2010_05 |
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