N-Iodosuccinimide → 3-Iodo-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-1H-indole TFA

HRID 2234074Notes

Reaction equation

HRID 2234074 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][O:9][C:10]1[N:11]=[N:12][C:13]([C:25]2[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=2)=[CH:14][C:15]=1[C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][CH:21]=[CH:20][CH:19]=2.[I:31]N1C(=O)CCC1=O>CC(C)=O>[OH:5][C:3]([C:2]([F:7])([F:6])[F:1])=[O:4].[I:31][C:24]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[NH:17][C:16]=1[C:15]1[CH:14]=[C:13]([C:25]2[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=2)[N:12]=[N:11][C:10]=1[O:9][CH3:8]

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 230924532-(3-Methoxy-6-pyridin-4-yl-pyridazin-4-yl)-1H-indole trifluoroacetate

Product 1

HCID 866120493-Iodo-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-1H-indole TFA

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A suspension of 2 g 2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-1H-indole trifluoroacetate and 1.3 g N-Iodosuccinimide (NIS) in acetone is stirred for 4 h at ambient temperature. The product is isolated by filtration, washed with acetone and used without further purification

Workup

  1. customThe product is isolated by filtration
  2. washwashed with acetone
  3. customused without further purification

Sources & evidence

ORD record
ord-6cc516e1524f465588bc8b290afb3149
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Reaction notes

Loading…