反应详情

A solution of 14 μl formaldehyde (37% solution in water) and 17 μl morpholine in 0.5 ml glacial acetic acid is added dropwise at 0° C. to 50 mg 4-(1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one suspended in 2.24 ml glacial acetic acid and 2.6 ml 1,4-dioxan. The resulting mixture is stirred for 3 h at room temperature, subsequently poured into ice/water and the pH is adjusted to 13.3 with 2N sodium hydroxide. The product is isolated by filtration.

1. customThe product is isolated by filtration